Yeah, the Conficker worm is supposed to update on April 1. Stick to standard protocols, use Windows Update if you aren’t already doing it automatically, run a thorourgh virus scan with your favorite anti-virus, give the machine a quick check with something like Lavasoft Adaware, and TURN YOUR MACHINE OFF IF YOU AREN’T USING IT.
I wouldn’t be totally surprised if the Conficker worm turned out to be an “April Fool’s Joke,” but of course doing nothing still isn’t worth the risk